منابع مشابه
type . Systemic amyloidosis of beta 2 microglobulin
A patient receiving haemodialysis for 15 years developed systemic amyloidosis of I2 microglobulin type. Noticeable deposits of amyloid were present in the myocardium, intervertebral discs, joint cartilages and tendons. Less conspicuous amounts were present in blood vessel walls in the lungs, liver, adrenal glands and brain, and within the stroma of the prostate, testis and kidney, often with fo...
متن کاملSystemic Amyloidosis: Lessons from β2-Microglobulin*
β2-Microglobulin is responsible for systemic amyloidosis affecting patients undergoing long-term hemodialysis. Its genetic variant D76N causes a very rare form of familial systemic amyloidosis. These two types of amyloidoses differ significantly in terms of the tissue localization of deposits and for major pathological features. Considering how the amyloidogenesis of the β2-microglobulin mechan...
متن کاملBeta 2 microglobulin haemodialysis related amyloidosis: distinctive gross features of gastrointestinal involvement.
Two cases of beta 2 microglobulin amyloidosis following long term haemodialysis found during necropsy are reported. The patients were 59 and 65 year old Japanese men, respectively. In both cases, systemic distribution of beta 2 microglobulin amyloid deposits was observed. The gastrointestinal tract including the stomach, small intestine, and colon showed the distinctive gross feature of rippled...
متن کاملbeta(2)-Microglobulin-selective direct hemoperfusion column for the treatment of dialysis-related amyloidosis.
Lixelle is a direct hemoperfusion-type adsorption column that was developed to selectively eliminate beta2-microglobulin (beta2-m) from the circulating blood of patients with dialysis-related amyloidosis (DRA). The adsorbent in Lixelle comprises porous cellulose beads to which hydrophobic hexadecyl alkyl chain is covalently bound. One milliliter of wet Lixelle beads eliminates more than 1 mg of...
متن کاملbeta 2-Microglobulin modified with advanced glycation end products is a major component of hemodialysis-associated amyloidosis.
beta 2-Microglobulin (beta 2M) is a major constituent of amyloid fibrils in hemodialysis-associated amyloidosis, a complication of long-term hemodialysis patients. Amyloid fibril proteins were isolated from connective tissues forming carpal tunnels in hemodialysis patients with carpal tunnel syndrome. Two-dimensional polyacrylamide gel electrophoresis and Western blotting demonstrated that most...
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ژورنال
عنوان ژورنال: Nephrology
سال: 1996
ISSN: 1320-5358,1440-1797
DOI: 10.1111/j.1440-1797.1996.tb00117.x